Binding free energy differences in a TCR-peptide-MHC complex induced by a peptide mutation: a simulation analysis.

@article{Michielin2002BindingFE,
  title={Binding free energy differences in a TCR-peptide-MHC complex induced by a peptide mutation: a simulation analysis.},
  author={Olivier Michielin and Martin Karplus},
  journal={Journal of molecular biology},
  year={2002},
  volume={324 3},
  pages={547-69}
}
Recognition by the T-cell receptor (TCR) of immunogenic peptides presented by class I major histocompatibility complexes (MHCs) is the determining event in the specific cellular immune response against virus-infected cells or tumor cells. It is of great interest, therefore, to elucidate the molecular principles upon which the selectivity of a TCR is based. These principles can in turn be used to design therapeutic approaches, such as peptide-based immunotherapies of cancer. In this study, free… CONTINUE READING

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