Binding energy and catalysis: a lesson from protein engineering of the tyrosyl-tRNA synthetase

@inproceedings{Fersht1986BindingEA,
  title={Binding energy and catalysis: a lesson from protein engineering of the tyrosyl-tRNA synthetase},
  author={A. R. Fersht and Robin J. Leatherbarrow and Timothy N. C. Wells},
  year={1986}
}
Abstract Dissection of the active site of the tyrosyl-tRNA synthetase has revealed the roles of individual side chains at each stage in the formation of tyrosyl adenylate. Catalysis results from a series of small interactions with the enzyme that conspire to ease the reagents into the transition state and then stabilize the high energy intermediate.