Binding constants determination of cyclodextrin inclusion complexes by affinity capillary electrophoresis. How to overcome the limitations induced by the UV-detector?

@article{Bertaut2020BindingCD,
  title={Binding constants determination of cyclodextrin inclusion complexes by affinity capillary electrophoresis. How to overcome the limitations induced by the UV-detector?},
  author={El{\'e}onore Bertaut and J. Goossens and D. Landy and C. Danel},
  journal={Journal of chromatography. A},
  year={2020},
  volume={1623},
  pages={
          461209
        }
}
  • Eléonore Bertaut, J. Goossens, +1 author C. Danel
  • Published 2020
  • Chemistry, Medicine
  • Journal of chromatography. A
  • In most cases, determination of binding constant for analyte-cyclodextrin complexes in capillary electrophoresis is investigated by affinity capillary electrophoresis using a UV detector (ACE-UV). The limitations induced by the UV-detector include : (i) the difficulty of dealing with poor chromogenic analytes and more generally with any analyte presenting strong affinity towards the cyclodextrin (CD), i.e. for which the prerequisite to work with analyte concentration much smaller than those of… CONTINUE READING

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