Binding characteristics of remoxipride and its metabolites to dopamine D2 and D3 receptors.

@article{Mohell1993BindingCO,
  title={Binding characteristics of remoxipride and its metabolites to dopamine D2 and D3 receptors.},
  author={Nina Mohell and Maria S{\"a}llemark and Seema Bairoliya Rosqvist and Asa Malmberg and Thomas H{\"o}gberg and David M. Jackson},
  journal={European journal of pharmacology},
  year={1993},
  volume={238 1},
  pages={121-5}
}
The substituted benzamide, remoxipride, is a new atypical antipsychotic agent with good clinical efficacy and low extrapyramidal side-effect potential. In the present study, the in vitro receptor binding properties of remoxipride and several of its metabolites to rat striatal dopamine D2 and cloned human dopamine D2A and D3 receptors were investigated. Remoxipride bound to [3H]raclopride-labelled dopamine D2 receptors in rat striatum with an affinity (Ki) of 113 nM. The significantly lower… CONTINUE READING

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