Binding characteristics of aromatase inhibitors and phytoestrogens to human aromatase

@article{Chen1997BindingCO,
  title={Binding characteristics of aromatase inhibitors and phytoestrogens to human aromatase},
  author={S. Chen and Y. Kao and C. Laughton},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={1997},
  volume={61},
  pages={107-115}
}
We have evaluated the binding characteristics of three steroidal inhibitors [4-hydroxyandrostenedione (4-OHA), 7alpha-(4'-amino)phenylthio-1,4-androstadiene-3,17-dione (7alpha-APTADD), and bridge (2,19-methyleneoxy) androstene-3,17-dione (MDL 101,003)], four nonsteroidal inhibitors [aminoglutethimide (AG), CGS 20267, ICI D1033, and vorozole (R83842)], and two flavone phytoestrogens (chrysin, and 7,8-dihydroxyflavone) to aromatase through a combination of computer modeling and inhibitory profile… Expand
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