Binding characteristics of [3H]guanfacine to rat brain alpha-adrenoceptors. Comparison with [3H]clonidine.

@article{Timmermans1982BindingCO,
  title={Binding characteristics of [3H]guanfacine to rat brain alpha-adrenoceptors. Comparison with [3H]clonidine.},
  author={Pieter B.M.W.M. Timmermans and Andreas Schoop and Pieter A. van Zwieten},
  journal={Biochemical pharmacology},
  year={1982},
  volume={31 6},
  pages={
          899-905
        }
}
Binding characteristics of [3H]quinupramine to rat brain membrane fractions.
TLDR
The specific binding of [3H]quinupramine observed here can be accounted for by both muscarinic cholinergic and serotonin S2 receptors.
Quantitative description of α2-adrenergic potency in terms of receptor affinity and intrinsic activity
TLDR
The results support current concepts in receptor theory stating that only when both efficacy and affinity are known, can the activity of the agonist be predicted with reasonable certainty.
Biochemistry of alpha-2 Adrenergic Receptors
TLDR
Physiologic and pharmacologic studies provide the present basis for the classification of alpha-adrenergic receptors and call for the existence of discrete alpha-1 and alpha-2 adrenergic receptors with the extant possibility of further subdivision among the alpha- 2 adrenergic receptor subtypes.
Animal pharmacology of guanfacine.
  • G. Scholtysik
  • Biology, Medicine
    The American journal of cardiology
  • 1986
Characterization of flufylline, fluprofylline, ritanserin, butanserin and R 56413 with respect to in‐vivo α1‐, α2‐ and 5‐HT2‐receptor antagonism and in‐vitro affinity for α1‐, α2‐ and 5‐HT2‐receptors: comparison with ketanserin
TLDR
It is concluded that of the compounds investigated butanserin is the most potent and selective α1‐adrenoceptor antagonist, whereas ritanserin was found to be a potent and select 5‐HT2‐antagonist.
Antihypertensive Activity of 2[(2-Hydroxyphenyl) amino] -4(3H)-quinazolinone
TLDR
Two 2-substituted 4(3H)-quinazolinones were synthesized through an easy one-step synthetic procedure and one contained a guanidino moiety and showed antihypertensive activity following cumulative intravenous administration to anesthetized spontaneously hypertensive rats.
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