Binding characteristics between poly(ethylene glycol) and hydrophilic modified ibuprofen in aqueous solution.

@article{Wei2010BindingCB,
  title={Binding characteristics between poly(ethylene glycol) and hydrophilic modified ibuprofen in aqueous solution.},
  author={D. Wei and Lingling Ge and R. Guo},
  journal={The journal of physical chemistry. B},
  year={2010},
  volume={114 10},
  pages={
          3472-81
        }
}
  • D. Wei, Lingling Ge, R. Guo
  • Published 2010
  • Chemistry, Medicine
  • The journal of physical chemistry. B
  • The solubility of ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), is enhanced by synthesizing ibuprofen ester with a water-soluble polymer, poly(ethylene glycol) (PEG), and the product obtained functions as a nonionic surfactant (IBF-PEG800, IP800). The morphology and aggregation behavior of IP800 micelles and IP800/PEG complexes in aqueous solution are investigated by (1)H NMR technology, dynamic light scattering (DLS), isothermal titration calorimetry (ITC), and fluorescence… CONTINUE READING
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