Binding and transport of gangliosides by prosaposin.

  title={Binding and transport of gangliosides by prosaposin.},
  author={Masao Hiraiwa and S Soeda and Yasuo Kishimoto and John S. O'brien},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={89 23},
Prosaposin, the precursor of saposins A, B, C, and D, which activate lysosomal hydrolysis of sphingolipids, exists in various tissues and body fluids and is especially abundant in the nervous system. Prosaposin and saposins A,B, C, and D formed stable complexes with 13 different gangliosides as measured by an assay using column chromatography. Gangliosides of the gangliotetraose type (a series) were bound with high affinity, whereas b series gangliosides, O-acetylated gangliosides, and… CONTINUE READING


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