Binding and repression of the latency-associated promoter of herpes simplex virus by the immediate early 175K protein.

@article{Batchelor1994BindingAR,
  title={Binding and repression of the latency-associated promoter of herpes simplex virus by the immediate early 175K protein.},
  author={A H Batchelor and Kent W Wilcox and Peter G O'Hare},
  journal={The Journal of general virology},
  year={1994},
  volume={75 ( Pt 4)},
  pages={753-67}
}
We demonstrate that the immediate early 175K protein (IE175K) of herpes simplex virus type 1 binds to the cap site of the latency-associated promoter (LAP) in an unusual manner. The complex formed on the LAP cap site was significantly larger than that formed on the IE175K cap site and the requirements for binding were qualitatively distinct with respect to both the primary sequence determinants at the site, and the regions of IE175K protein required for binding compared to those for the IE175K… CONTINUE READING

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