Binding and release of the 6 S transcriptional control RNA Material

@inproceedings{Shephard2010BindingAR,
  title={Binding and release of the 6 S transcriptional control RNA Material},
  author={Lindsay Shephard and Neil Dobson and Peter J. Unrau},
  year={2010}
}
6S RNA is an important noncoding RNA that regulates eubacterial transcription. In Escherichia coli this RNA binds to the s RNA polymerase holoenzyme and is released by the synthesis of a short product RNA. In order to determine how binding and release are controlled by the 6S RNA sequence, we used in vitro selection to screen a high diversity library containing ;4 3 10 sequences for functional 6S RNA variants. Residues critical for binding were found to be located in a ‘‘-35’’ region upstream… CONTINUE READING
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