Binding and neutralization activity of human IgG1 and IgG3 from serum of HIV-infected individuals.

@article{Cavacini2003BindingAN,
  title={Binding and neutralization activity of human IgG1 and IgG3 from serum of HIV-infected individuals.},
  author={Lisa A Cavacini and David M. Kuhrt and Mark Duval and Kenneth H. Mayer and Marshall Roy Posner},
  journal={AIDS research and human retroviruses},
  year={2003},
  volume={19 9},
  pages={785-92}
}
The IgG1 and IgG3 subclasses represent the predominant antibody response to viral infections, including HIV. IgG subclasses differ in their interaction with antigen and functional effects due to specific physiochemical features. With an elongated hinge, IgG3 antibodies tend to have more segmental flexibility, which can render the antibody more effective at interacting with antigen. We have previously shown that the change of the human anti-CD4-binding site monoclonal antibody F105 from IgG1 to… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

Similar Papers

Loading similar papers…