Binding and localization of recombinant lubricin to articular cartilage surfaces.

@article{Jones2007BindingAL,
  title={Binding and localization of recombinant lubricin to articular cartilage surfaces.},
  author={Aled R C Jones and Jason P. Gleghorn and Clare Hughes and Lori J. Fitz and R. Christian Zollner and Shane Daniel Wainwright and Bruce Caterson and Elisabeth A. Morris and Lawrence J. Bonassar and Carl R. Flannery},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={2007},
  volume={25 3},
  pages={
          283-92
        }
}
Lubricin is a secreted, cytoprotective glycoprotein that contributes to the essential boundary lubrication mechanisms necessary for maintaining low friction levels at articular cartilage surfaces. Diminishment of lubricin function is thereby implicated as an adverse contributing factor in degenerative joint diseases such as osteoarthritis. Lubricin occurs as a soluble component of synovial fluid, and is synthesized and localized in the superficial layer of articular cartilage (and thus has also… CONTINUE READING
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