Binding and internalization of leptin by porcine choroid plexus cells in culture.

@article{Peiser2000BindingAI,
  title={Binding and internalization of leptin by porcine choroid plexus cells in culture.},
  author={C Peiser and Gerard Patrick McGregor and Rudolf E. Lang},
  journal={Neuroscience letters},
  year={2000},
  volume={283 3},
  pages={209-12}
}
Leptin is an adipocyte derived hormone with profound behavioural and metabolic effects exerted by both central and peripheral sites of action. One of its targets in the central nervous system appears to be the epithelial cells of the choroid plexus where leptin receptor (OB-R) expression is particularly high. The most abundant receptor subtype at this site is OB-Ra which is truncated at its intracellular part and has been suggested to serve functions such as leptin transport or clearance. The… CONTINUE READING

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