Binding and internalization of NGR-peptide-targeted liposomal doxorubicin (TVT-DOX) in CD13-expressing cells and its antitumor effects.

@article{Garde2007BindingAI,
  title={Binding and internalization of NGR-peptide-targeted liposomal doxorubicin (TVT-DOX) in CD13-expressing cells and its antitumor effects.},
  author={Seema V. Garde and Andr{\'e} J Fort{\'e} and Michael Ge and Eugene A. Lepekhin and Chandra J. Panchal and Shafaat A. Rabbani and Jinzi J. Wu},
  journal={Anti-cancer drugs},
  year={2007},
  volume={18 10},
  pages={1189-200}
}
In an effort to develop new agents and molecular targets for the treatment of cancer, aspargine-glycine-arginine (NGR)-targeted liposomal doxorubicin (TVT-DOX) is being studied. The NGR peptide on the surface of liposomal doxorubicin (DOX) targets an aminopeptidase N (CD13) isoform, specific to the tumor neovasculature, making it a promising strategy. To further understand the molecular mechanisms of action, we investigated cell binding, kinetics of internalization as well as cytotoxicity of… CONTINUE READING

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