Binding and functional properties of endothelin receptor subtypes in the human prostate.

@article{Kobayashi1994BindingAF,
  title={Binding and functional properties of endothelin receptor subtypes in the human prostate.},
  author={Satoru Kobayashi and Ren Yuan Tang and Bao-jun Wang and Terry J. Opgenorth and Peter Langenstroer and Ellen Shapiro and Herbert Lepor},
  journal={Molecular pharmacology},
  year={1994},
  volume={45 2},
  pages={306-11}
}
The objective of the present study was to characterize the binding and functional properties of endothelin (ET) receptor subtypes in the human prostate. Human prostatic tissue was obtained from male subjects undergoing radical prostatectomy for low-volume prostate cancer. The optimal assay conditions for characterizing human prostatic ET-1 binding sites on slide-mounted tissue sections were defined. Maximal specific 125I-ET-1 binding was achieved after a 10-min preincubation, a 120-min… CONTINUE READING

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