Binding and functional comparisons of two types of tumor necrosis factor antagonists.

@article{Scallon2002BindingAF,
  title={Binding and functional comparisons of two types of tumor necrosis factor antagonists.},
  author={Bernard J. Scallon and Ann Cai and Nancy L Solowski and Amy S. Rosenberg and Xiao-yu Song and David J Shealy and Carrie L. Wagner},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2002},
  volume={301 2},
  pages={
          418-26
        }
}
  • B. ScallonAnn Cai C. Wagner
  • Published 1 May 2002
  • Biology, Medicine
  • The Journal of pharmacology and experimental therapeutics
Two tumor necrosis factor (TNF) antagonists infliximab (a chimeric monoclonal antibody) and etanercept (a p75 TNF receptor/Fc fusion protein) have been approved for treatment of rheumatoid arthritis. However, these agents have shown different degrees of clinical benefit in controlled clinical trials in other TNF-mediated diseases such as Crohn's disease (CD) and psoriasis. We investigated whether structural differences between these two antagonists translate into different binding and… 

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