Binding and functional characterization of the cardioselective muscarinic antagonist methoctramine.

@article{Giraldo1988BindingAF,
  title={Binding and functional characterization of the cardioselective muscarinic antagonist methoctramine.},
  author={E. Giraldo and Rosella Micheletti and Emilia Montagna and Antonio Giachetti and M. Alessandra Vigano and Herbert Ladinsky and Carlo Melchiorre},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1988},
  volume={244 3},
  pages={1016-20}
}
The antimuscarinic properties of the newly synthetized polymethylene tetramine derivative, methoctramine, were investigated in binding and functional assays. Methoctramine displaced the specific binding of [3H]-N-methylscopolamine [( 3H]NMS) and [3H] pirenzepine from membranes of rat tissues with the following order of affinities: heart = cerebellum greater than cortex greater than submandibular glands, the ratio of the affinities of the compound for the heart and the glands amounting to about… CONTINUE READING
15 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 15 extracted citations

Similar Papers

Loading similar papers…