Binding and function of serotonin 2 receptors following chronic administration of imipramine.

@article{McDONALD1984BindingAF,
  title={Binding and function of serotonin 2 receptors following chronic administration of imipramine.},
  author={DALE McDONALD and George M. Stancel and Sam J Enna},
  journal={Neuropharmacology},
  year={1984},
  volume={23 11},
  pages={1265-9}
}
Experiments were undertaken to determine whether alterations in the binding of 5-HT2 receptors in the cerebral cortex of rat brain, induced by antidepressant drugs, are related to behavioral changes observed in response to the administration of a precursor of serotonin. Chronic (5 days), but not acute, administration of an imipramine-yohimbine combination resulted in a significant decrease in the binding of 5-HT2 receptors in the frontal cortex and wet-dog shakes induced by 5-hydroxytryptophan… CONTINUE READING