Binding and cytotoxic trafficking of cholesterol hydroperoxides by sterol carrier protein-2.

Abstract

Redox-active cholesterol hydroperoxides (ChOOHs) generated by oxidative stress in eukaryotic cells may propagate cytotoxic membrane damage by undergoing one-electron reduction or, at low levels, act as mobile signaling molecules like H2O2. We discovered that ChOOHs can spontaneously translocate between membranes or membranes and lipoproteins in model… (More)
DOI: 10.1007/978-1-4939-1441-8_30

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