Binding and catalysis by yeast aldose reductase: a substrate-analog approach with new aldose derivatives.

Abstract

5-Deoxy-D-xylofuranose derivatives and a range of new 5,6-dideoxy analogs of D-glucofuranose bearing azido or fluoro substituents were synthesised and employed as substrates of the NADH-dependent aldehyde reduction catalysed by yeast aldose reductase. In terms of catalytic efficiencies, these products proved to be superior to the parent compounds.

Cite this paper

@article{Hadwiger1999BindingAC, title={Binding and catalysis by yeast aldose reductase: a substrate-analog approach with new aldose derivatives.}, author={Philipp Hadwiger and Peter Mayr and A Tauss and Arnold E. St{\"{u}tz and Bernd Nidetzky}, journal={Bioorganic & medicinal chemistry letters}, year={1999}, volume={9 12}, pages={1683-6} }