Binding and biological activity of C-terminally modified melanocortin peptides: a comparison between their actions at rodent MC1 and MC3 receptors.

@article{Peng1997BindingAB,
  title={Binding and biological activity of C-terminally modified melanocortin peptides: a comparison between their actions at rodent MC1 and MC3 receptors.},
  author={P J Peng and Ursula Sahm and Rebecca Doherty and R. G. Kinsman and Scott H. Moss and Colin W. Pouton},
  journal={Peptides},
  year={1997},
  volume={18 7},
  pages={1001-8}
}
Five subtypes of melanocortin receptors have to date been identified, but to date little is known about the different structural requirements for binding and biological activity at these receptors. In this study, the role of C-terminal melanocortin peptide residues in imparting selectivity for the receptor subtypes was examined. C-terminally modified analogues of alpha-MSH and gamma-MSH were synthesized and their interaction with MC1 and MC3 melanocortin receptors was investigated. This study… CONTINUE READING