Binding and biologic activity of neurotensin in guinea pig ileum

  title={Binding and biologic activity of neurotensin in guinea pig ileum},
  author={R. Carraway and S. P. Mitra},
  • R. Carraway, S. P. Mitra
  • Published 1994
  • Chemistry, Medicine
  • Peptides
  • Experiments were performed to relate receptor binding to biologic activity for the contractile effect of neurotensin (NT) in guinea pig ileum. The contractile response was examined on pieces of ileum under 1 g tension in a 5 ml bath of oxygenated Tyrode's at 38 degrees C. NT contracted the longitudinal muscle (ED50, approximately 0.3 nM), the 2-3 g response peaking at 1 min and fading rapidly. In the presence of atropine (1 microM), > or = 50% of the response was blocked and the residual effect… CONTINUE READING
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