• DOI:10.1016/0196-9781(94)90123-6
Corpus ID: 3831395

Binding and biologic activity of neurotensin in guinea pig ileum

@article{Carraway1994BindingAB,
  title={Binding and biologic activity of neurotensin in guinea pig ileum},
  author={R. Carraway and S. P. Mitra},
  journal={Peptides},
  year={1994},
  volume={15},
  pages={1451-1459}
}

R. Carraway, S. P. Mitra

Published 1994

Chemistry, Medicine

Peptides

Experiments were performed to relate receptor binding to biologic activity for the contractile effect of neurotensin (NT) in guinea pig ileum. The contractile response was examined on pieces of ileum under 1 g tension in a 5 ml bath of oxygenated Tyrode's at 38 degrees C. NT contracted the longitudinal muscle (ED50, approximately 0.3 nM), the 2-3 g response peaking at 1 min and fading rapidly. In the presence of atropine (1 microM), > or = 50% of the response was blocked and the residual effect… CONTINUE READING

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