Binding affinity analysis and ADMET prediction of epigallocatechine gallate (EGCG) derivatives for AP-1 protein: a drug target for liver cancer

@article{Sagar2014BindingAA,
  title={Binding affinity analysis and ADMET prediction of epigallocatechine gallate (EGCG) derivatives for AP-1 protein: a drug target for liver cancer},
  author={Mamta Sagar and Rajesh Kumar Pathak and Rishi Kumar Pandey and Dev Bukhsh Singh and Neetesh Pandey and Manish Kumar Gupta},
  journal={Network Modeling Analysis in Health Informatics and Bioinformatics},
  year={2014},
  volume={3},
  pages={1-13}
}
The hepatitis B virus × protein (HBx) of Hepatitis B virus activates AP-1 protein and causes the down regulation of PTEN (full name) and p53 leads to the tumor formation in liver. In this study, the interactions between DNA and AP-1 have been targeted by docking of natural compounds epigallocatechine gallate (EGCG), curcumin, luteoline, genistein, ellagic… CONTINUE READING