Binding Sites for Acylated Trehalose Analogs of Glycolipid Ligands on an Extended Carbohydrate Recognition Domain of the Macrophage Receptor Mincle*

@inproceedings{Feinberg2016BindingSF,
  title={Binding Sites for Acylated Trehalose Analogs of Glycolipid Ligands on an Extended Carbohydrate Recognition Domain of the Macrophage Receptor Mincle*},
  author={Hadar Feinberg and Neela Devi Sing Rambaruth and Sabine A. F. J{\'e}gouzo and Kristian M Jacobsen and Rasmus Djurhuus and Thomas B Poulsen and William I Weis and M Evangeline Taylor and Kurt Drickamer},
  booktitle={The Journal of biological chemistry},
  year={2016}
}
The macrophage receptor mincle binds to trehalose dimycolate on the surface of Mycobacterium tuberculosis Signaling initiated by this interaction leads to cytokine production, which underlies the ability of mycobacteria to evade the immune system and also to function as adjuvants. In previous work the mechanism for binding of the sugar headgroup of… CONTINUE READING

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