Binding STAT2 by the acidic domain of human cytomegalovirus IE1 promotes viral growth and is negatively regulated by SUMO.

@article{Huh2008BindingSB,
  title={Binding STAT2 by the acidic domain of human cytomegalovirus IE1 promotes viral growth and is negatively regulated by SUMO.},
  author={Yong Ho Huh and Young Eui Kim and Eui Tae Kim and Jung Jin Park and Moon Jung Song and Hua Zhu and Gary Selwyn Hayward and Jin-Hyun Ahn},
  journal={Journal of virology},
  year={2008},
  volume={82 21},
  pages={
          10444-54
        }
}
The human cytomegalovirus (HCMV) 72-kDa immediate-early 1 (IE1) protein is thought to modulate cellular antiviral functions impacting on promyelocytic leukemia (PML) nuclear bodies and signal transducer and activator of transcription (STAT) signaling. IE1 consists of four distinct regions: an amino-terminal region required for nuclear localization, a large central hydrophobic region responsible for PML targeting and transactivation activity, an acidic domain, and a carboxyl-terminal chromatin… CONTINUE READING
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