Binding Affinity of Metal Ions to the CD11b A-domain Is Regulated by Integrin Activation and Ligands.

@article{Ajroud2004BindingAO,
  title={Binding Affinity of Metal Ions to the CD11b A-domain Is Regulated by Integrin Activation and Ligands.},
  author={Kaouther Ajroud and Takashi Sugimori and Wolfgang Heinrich Goldmann and Dahmani M. Fathallah and Jian Xiong and M. Amin Arnaout},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 24},
  pages={25483-8}
}
The divalent cations Mg(2+) and Ca(2+) regulate the interaction of integrins with their cognate ligands, with Mg(2+) uniformly facilitating and Ca(2+) generally inhibiting such interactions in vitro. Because both cations are present in mm concentrations in vivo, the physiologic relevance of the in vitro observations is unclear. We measured the affinity of both cations to the inactive and active states of the ligand- and cation-binding A-domain (CD11bA) from integrin CD11b/CD18 in the absence… CONTINUE READING

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