Binary switches and modification cassettes in histone biology and beyond

  title={Binary switches and modification cassettes in histone biology and beyond},
  author={Wolfgang Fischle and Yanming Wang and C David Allis},
An immense number of post-translational modifications on histone proteins have been described and additional sites of modification are still being uncovered. Whereas many direct and indirect connections between certain histone modifications and distinct biological phenomena have now been established, concepts for comprehending the extreme density and variety of these covalent modifications are lacking. Here, we formally introduce localized ‘binary switches’ and ‘modification cassettes’ as new… CONTINUE READING

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