Binary combinations of organophosphorus and synthetic pyrethroids are more potent acetylcholinesterase inhibitors than organophosphorus and carbamate mixtures: An in vitro assessment.

@article{Arora2017BinaryCO,
  title={Binary combinations of organophosphorus and synthetic pyrethroids are more potent acetylcholinesterase inhibitors than organophosphorus and carbamate mixtures: An in vitro assessment.},
  author={Sumitra Arora and Sahil Balotra and Gunjan Pandey and Anu Kumar},
  journal={Toxicology letters},
  year={2017},
  volume={268},
  pages={
          8-16
        }
}
In vitro and in vivo effects of chlorpyrifos and cypermethrin on blood cholinesterases in sheep.
TLDR
Evaluated the inhibitory potency of both pesticides, alone and in combination with AChE and butyrylcholinesterase activities in sheep blood to contribute to the knowledge of the risks of implementing higher dosage regimens of OPs-containing antiparasitic formulations.
Screening of Carbamate and Organophosphate Pesticides in Food Matrices Using an Affordable and Simple Spectrophotometric Acetylcholinesterase Assay
TLDR
The developed AChE assay achieved low limits of detection at the part per billion (ppb) level, depending the analyte inhibitory strength, recovery rates higher than 70% and good repeatability, and may find application as a low-cost pre-screening tool of A ChE inhibitors presence.
Evaluation of Resistance to Some Pyrethroid and Organophosphate Insecticides and Their Underlying Impact on the Activity of Esterases and Phosphatases in House Fly, Musca domestica (Diptera: Muscidae)
TLDR
Deltamethrin inhibited the maximum activity of AChE (50%), whereas, DDVP caused maximum inhibition of acid phosphatases, which suggested that house fly populations are more resistant to pyrethroids compared to organophosphate insecticides.
Lethal and sublethal responses in the fish, Odontesthes bonariensis, exposed to chlorpyrifos alone or under mixtures with endosulfán and lambda-cyhalothrin
TLDR
Evaluated lethal and sublethal effects of CPF, singly or in mixtures, on the inland “Pejerrey” (Odontesthes bonariensis) under laboratory conditions found differential sensitivity to CPF was found, placing this Neotropical species among the 13% of worldwide fish more sensitive toCPF.
Impact of pesticide coexposure: an experimental study with binary mixtures of lambda-cyhalothrin (LCT) and captan and its impact on the toxicokinetics of LCT biomarkers of exposure
TLDR
The results suggest that the pyrethroid metabolites CFMP and 3-PBA, mostly measured in biomonitoring studies, remain useful as biomarkers of exposure in mixtures, when pesticide exposure levels are below the reference values.
Ensuring traceability of organophosphate pesticides (OPs) through enzyme immobilized spheres
TLDR
The developed colorimetric process showed good qualitative analytical performance for Phosmet (OPs) detection as low as 10−7 M and was found to have the ability to catalyze the hydrolysis of ATCl with an apparent Michaelis–Menten constant value of 288 mM.
In search of a comprehensible set of endpoints for the routine monitoring of neurotoxicity in vertebrates: sensory perception and nerve transmission in zebrafish (Danio rerio) embryos
TLDR
Since acetylcholinesterase inhibition and neuromast degeneration can be analyzed in 72- and 96-h-old zebrafish embryos exposed to neurotoxicants according to the standard protocol of the fish embryo toxicity test (OECD TG 236), the fish embryos toxicity test can be enhanced to serve as a sensitive neurotoxicity screening test in non-protected stages of vertebrates.
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