Bimonthly high-dose leucovorin, 5-fluorouracil infusion and oxaliplatin (FOLFOX3) for metastatic colorectal cancer resistant to the same leucovorin and 5-fluorouracil regimen.

@article{Andr1998BimonthlyHL,
  title={Bimonthly high-dose leucovorin, 5-fluorouracil infusion and oxaliplatin (FOLFOX3) for metastatic colorectal cancer resistant to the same leucovorin and 5-fluorouracil regimen.},
  author={Thierry Andr{\'e} and Christophe Louvet and Eric Raymond and Christophe Tournigand and Aimery de Gramont},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={1998},
  volume={9 11},
  pages={1251-3}
}
BACKGROUND FOLFOX2, a bimonthly regimen of high-dose leucovorin (LV), 48-hour continuous infusion of 5-fluorouracil (5-FU) (LV-5-FU) and oxaliplatin (100 mg/m2) produced a high response rate (46%; 95% confidence interval (95% CI): 31%-60%) in 5-FU pre-treated patients with metastatic colorectal cancer. In this phase II study, pre-treated patients were given a lower dose of oxaliplatin to reduce the toxic effects of the regimen. PATIENTS AND METHODS Thirty patients with advanced colorectal… CONTINUE READING

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Addition of oxaliplatin (Eloxatine) to the same leucovorin (LV) and 5-fluorouracil (5-FU) bimonthly regimens after progression in patients with metastatic colorectal cancer

  • T Andre, MA Bensmaine, C Louvet
  • (MCRQ: Proceedings of the Annual Meeting ECCO 9…
  • 1997
2 Excerpts

Bimonthly high-dose leucovorin and 5-fluorouracil 48-hour continuous infusion with a-2a-interferon in advanced colorectal cancer

  • C Tournigand, C Louvet, A de Gramont
  • Cancer
  • 1997
2 Excerpts

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