Bimolecular complementation defines functional regions of Herpes simplex virus gB that are involved with gH/gL as a necessary step leading to cell fusion.

@article{Atanasiu2010BimolecularCD,
  title={Bimolecular complementation defines functional regions of Herpes simplex virus gB that are involved with gH/gL as a necessary step leading to cell fusion.},
  author={Doina Atanasiu and J. Charles Whitbeck and Manuel Ponce de Leon and Huan Lou and Brian P. Hannah and Gary H Cohen and Roselyn J Eisenberg},
  journal={Journal of virology},
  year={2010},
  volume={84 8},
  pages={3825-34}
}
Herpes simplex virus (HSV) entry into cells requires four membrane glycoproteins: gD is the receptor binding protein, and gB and gH/gL constitute the core fusion machinery. Crystal structures of gD and its receptors have provided a basis for understanding the initial triggering steps, but how the core fusion proteins function remains unknown. The gB crystal structure shows that it is a class III fusion protein, yet unlike other class members, gB itself does not cause fusion. Bimolecular… CONTINUE READING

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