Bimodal regulation of p21waf1 protein as function of DNA damage levels

  title={Bimodal regulation of p21waf1 protein as function of DNA damage levels},
  author={Giacomo Buscemi and Claudio Ricci and Laura Zannini and Enrico Fontanella and P Plevani and Domenico Delia},
  booktitle={Cell cycle},
Human p21(Waf1) protein is well known for being transcriptionally induced by p53 and activating the cell cycle checkpoint arrest in response to DNA breaks. Here we report that p21(Waf1) protein undergoes a bimodal regulation, being upregulated in response to low doses of DNA damage but rapidly and transiently degraded in response to high doses of DNA lesions. Responsible for this degradation is the checkpoint kinase Chk1, which phosphorylates p21(Waf1) on T145 and S146 residues and induces its… CONTINUE READING
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