Bimodal opioid regulation of cyclic AMP formation: implications for positive and negative coupling of opiate receptors to adenylyl cyclase.

@article{Wang1994BimodalOR,
  title={Bimodal opioid regulation of cyclic AMP formation: implications for positive and negative coupling of opiate receptors to adenylyl cyclase.},
  author={Liping Wang and Alan R. Gintzler},
  journal={Journal of neurochemistry},
  year={1994},
  volume={63 5},
  pages={1726-30}
}
A mu-selective opiate receptor agonist, sufentanil, can either increase or decrease the stimulated formation of cyclic AMP (cAMP) in the myenteric plexus. The direction of the opioid modulation of this second messenger depends on the concentration of opioid used. Low doses of opioid enhance, whereas higher concentrations inhibit, the magnitude of cAMP that… CONTINUE READING