Bimodal modulation of tau protein phosphorylation and conformation by extracellular Zn2+ in human-tau transfected cells.

@article{Boom2009BimodalMO,
  title={Bimodal modulation of tau protein phosphorylation and conformation by extracellular Zn2+ in human-tau transfected cells.},
  author={Alain Boom and Mich{\`e}le Authelet and Robert Dedecker and Christelle Fr{\'e}d{\'e}rick and Roxane van Heurck and Val{\'e}ry Daubie and Karelle Leroy and Roland Pochet and J. -P. Brion},
  journal={Biochimica et biophysica acta},
  year={2009},
  volume={1793 6},
  pages={1058-67}
}
Abnormal homeostasis of heavy metals is a well-documented physiopathological mechanism in Alzheimer's disease. An exacerbation of these abnormalities is best illustrated in the amyloid plaques in Alzheimer's disease brain tissue, in which zinc reaches the enormous concentration of 1000 microM. Zinc in the plaques is thought to originate from impaired glutamatergic neurons distributed in the associative cortex and limbic structures of normal brain. Although the characteristics of zinc binding to… CONTINUE READING
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