Bimodal modulation by nicotine of anxiety in the social interaction test: role of the dorsal hippocampus.

@article{File1998BimodalMB,
  title={Bimodal modulation by nicotine of anxiety in the social interaction test: role of the dorsal hippocampus.},
  author={S. E. File and Paul J. Kenny and Abdel Ouagazzal},
  journal={Behavioral neuroscience},
  year={1998},
  volume={112 6},
  pages={1423-9}
}
In conditions generating moderate levels of anxiety in the social interaction test (low light, unfamiliar arena or high light, familiar arena), parenteral administration of nicotine had bimodal actions, low doses (0.01 and 0.1 mg/kg i.p.) had anxiolytic effects and high doses (0.5 and 1.0 mg/kg i.p.) had anxiogenic effects. In test conditions where anxiety was lowest (low light, familiar arena) and highest (high light, unfamiliar arena), nicotine was without effect after intraperitoneal or… CONTINUE READING
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