Bimodal expression of PHO84 is modulated by early termination of antisense transcription

@inproceedings{Castelnuovo2013BimodalEO,
  title={Bimodal expression of PHO84 is modulated by early termination of antisense transcription},
  author={Manuele Castelnuovo and Samir Rahman and Elisa Guffanti and Valentina Infantino and Françoise Stutz and Daniel Zenklusen},
  booktitle={Nature Structural &Molecular Biology},
  year={2013}
}
Many Saccharomyces cerevisiae genes encode antisense transcripts, some of which are unstable and degraded by the exosome component Rrp6. Loss of Rrp6 results in the accumulation of long PHO84 antisense (AS) RNAs and repression of sense transcription through PHO84 promoter deacetylation. We used single-molecule resolution fluorescent in situ hybridization (smFISH) to investigate antisense-mediated transcription regulation. We show that PHO84 AS RNA acts as a bimodal switch, in which continuous… CONTINUE READING
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