Bimodal Interaction of Mammalian Polo-Like Kinase 1 and a Centrosomal Scaffold, Cep192, in the Regulation of Bipolar Spindle Formation.

@article{Meng2015BimodalIO,
  title={Bimodal Interaction of Mammalian Polo-Like Kinase 1 and a Centrosomal Scaffold, Cep192, in the Regulation of Bipolar Spindle Formation.},
  author={Lingjun Meng and Jung-Eun · Lee Park and Tae-Sung Kim and Eun Hye Lee and Suk-Youl Park and Ming Zhou and Jeong Kyu Bang and Kyung Suk Lee},
  journal={Molecular and cellular biology},
  year={2015},
  volume={35 15},
  pages={2626-40}
}
Serving as microtubule-organizing centers, centrosomes play a key role in forming bipolar spindles. The mechanism of how centrosomes promote bipolar spindle assembly in various organisms remains largely unknown. A recent study with Xenopus laevis egg extracts suggested that the Plk1 ortholog Plx1 interacts with the phospho-T46 (p-T46) motif of Xenopus Cep192 (xCep192) to form an xCep192-mediated xAurA-Plx1 cascade that is critical for bipolar spindle formation. Here, we demonstrated that in… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.