Bimatoprost protects retinal neuronal damage via Akt pathway.

  title={Bimatoprost protects retinal neuronal damage via Akt pathway.},
  author={Norihito Takano and Kazuhiro Tsuruma and Yuta Ohno and Masamitsu Shimazawa and Hideaki Hara},
  journal={European journal of pharmacology},
  volume={702 1-3},
Worldwide, prostaglandin analogs, such as bimatoprost, have become the major therapeutic class for medical treatment of glaucoma because of their efficacy and generally well tolerated systemic safety profile. However, the detailed mechanism of the direct action of bimatoprost on retinal ganglion cells (RGC) has rarely been understood. Thus, in this study, we elucidated the mechanism of the protective effects of bimatoprost on RGC against oxidative stress. To examine the protective effects of… CONTINUE READING