Bim mediates apoptosis of CD127(lo) effector T cells and limits T cell memory.

@article{Wojciechowski2006BimMA,
  title={Bim mediates apoptosis of CD127(lo) effector T cells and limits T cell memory.},
  author={Sara E Wojciechowski and Michael B. Jordan and Yanan Zhu and Janice M. White and Allan J. Zajac and David A Hildeman},
  journal={European journal of immunology},
  year={2006},
  volume={36 7},
  pages={1694-706}
}
Following an acute T cell response, most activated effector cells die, while some survive and become memory cells. The pro-apoptotic Bcl-2 family member, Bcl-2 interacting mediator of death (Bim) is critical for eliminating most effector T cells, while expression of CD127 (IL-7Ralpha) has been proposed to mark effector cells destined to become memory cells. Here, we examined the effects of Bim on the death of effector T cells in relationship to CD127 expression and on development of T cell… CONTINUE READING

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