Bim and Bmf Synergize To Induce Apoptosis in Neisseria Gonorrhoeae Infection

@article{Kepp2009BimAB,
  title={Bim and Bmf Synergize To Induce Apoptosis in Neisseria Gonorrhoeae Infection},
  author={Oliver Kepp and Kathleen Gottschalk and Yuri Churin and Krishnaraj Rajalingam and V Brinkmann and Nikolaus Machuy and Guido Kroemer and Thomas Rudel},
  journal={PLoS Pathogens},
  year={2009},
  volume={5},
  pages={201 - 204}
}
Bcl-2 family proteins including the pro-apoptotic BH3-only proteins are central regulators of apoptotic cell death. Here we show by a focused siRNA miniscreen that the synergistic action of the BH3-only proteins Bim and Bmf is required for apoptosis induced by infection with Neisseria gonorrhoeae (Ngo). While Bim and Bmf were associated with the cytoskeleton of healthy cells, they both were released upon Ngo infection. Loss of Bim and Bmf from the cytoskeleton fraction required the activation… CONTINUE READING

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