Bim: a novel member of the Bcl‐2 family that promotes apoptosis

@article{OConnor1998BimAN,
  title={Bim: a novel member of the Bcl‐2 family that promotes apoptosis},
  author={L. O'Connor and A. Strasser and L. O'Reilly and G. Hausmann and J. Adams and S. Cory and D. C. Huang},
  journal={The EMBO Journal},
  year={1998},
  volume={17}
}
  • L. O'Connor, A. Strasser, +4 authors D. C. Huang
  • Published 1998
  • Biology, Medicine
  • The EMBO Journal
    • Certain members of the Bcl‐2 family inhibit apoptosis while others facilitate this physiological process of cell death. An expression screen for proteins that bind to Bcl‐2 yielded a small novel protein, denoted Bim, whose only similarity to any known protein is the short (nine amino acid) BH3 motif shared by most Bcl‐2 homologues. Bim provokes apoptosis, and the BH3 region is required for Bcl‐2 binding and for most of its cytotoxicity. Like Bcl‐2, Bim possesses a hydrophobic C‐terminus and… CONTINUE READING
    View on Wiley
    europepmc.org
    1,106 Citations
    Highly Influential Citations
    73
    Background Citations
    418
    Methods Citations
    22
    Results Citations
    13
    1,106 Citations
    Citation Type

    Citation Type

    The Role of Bim, a Proapoptotic BH3‐Only Member of the Bcl‐2 Family, in Cell‐Death Control
    • 144
    Identification of Novel Isoforms of the BH3 Domain Protein Bim Which Directly Activate Bax To Trigger Apoptosis
    • 297
    • PDF
    The conserved N‐terminal BH4 domain of Bcl‐2 homologues is essential for inhibition of apoptosis and interaction with CED‐4
    • 254
    • PDF
    Endogenous association of Bim BH3‐only protein with Mcl‐1, Bcl‐xL and Bcl‐2 on mitochondria in human B cells
    • 69
    Molecular cloning and characterization of six novel isoforms of human Bim, a member of the proapoptotic Bcl‐2 family1
    • 81
    Bim and the Pro-Survival Bcl-2 Proteins: Opposites Attract, ERK Repels
    • 138
    • PDF
    Direct addition of BimL to mitochondria does not lead to cytochrome c release
    • 53
    Identification and characterization of Bimgamma, a novel proapoptotic BH3-only splice variant of Bim.
    • 55
    The role of BH3-only protein Bim extends beyond inhibiting Bcl-2–like prosurvival proteins
    • 182
    • PDF
    Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1
    • 1,032
    • Highly Influenced

    References

    SHOWING 1-10 OF 96 REFERENCES
    The anti‐apoptosis function of Bcl‐2 can be genetically separated from its inhibitory effect on cell cycle entry
    • 339
    • PDF
    A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions.
    • 521
    Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak
    • 528
    BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax
    • 1,304
    • Highly Influential
    BID: a novel BH3 domain-only death agonist.
    • 935
    • Highly Influential
    • PDF
    Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death
    • 5,968
    Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death
    • 2,098
    • Highly Influential
    bcl-w, a novel member of the bcl-2 family, promotes cell survival.
    • 310
    Bax-independent inhibition of apoptosis by Bcl-XL
    • 497
    harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival‐promoting proteins Bcl‐2 and Bcl‐XL
    • 384
    • Highly Influential