Bim: a novel member of the Bcl‐2 family that promotes apoptosis

  title={Bim: a novel member of the Bcl‐2 family that promotes apoptosis},
  author={L. O'Connor and A. Strasser and L. O'Reilly and G. Hausmann and J. Adams and S. Cory and D. C. Huang},
  journal={The EMBO Journal},
  • L. O'Connor, A. Strasser, +4 authors D. C. Huang
  • Published 1998
  • Biology, Medicine
  • The EMBO Journal
  • Certain members of the Bcl‐2 family inhibit apoptosis while others facilitate this physiological process of cell death. An expression screen for proteins that bind to Bcl‐2 yielded a small novel protein, denoted Bim, whose only similarity to any known protein is the short (nine amino acid) BH3 motif shared by most Bcl‐2 homologues. Bim provokes apoptosis, and the BH3 region is required for Bcl‐2 binding and for most of its cytotoxicity. Like Bcl‐2, Bim possesses a hydrophobic C‐terminus and… CONTINUE READING
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