Biliverdin's regulation of reactive oxygen species signalling leads to potent inhibition of proliferative and angiogenic pathways in head and neck cancer

@inproceedings{Zheng2014BiliverdinsRO,
  title={Biliverdin's regulation of reactive oxygen species signalling leads to potent inhibition of proliferative and angiogenic pathways in head and neck cancer},
  author={Junnian Zheng and Danish A. Nagda and Shayanne A. Lajud and Sushil Kumar and A Mouchli and O Bezpalko and Bert W O'malley and D Daqing Li},
  booktitle={British Journal of Cancer},
  year={2014}
}
Background:In this study, we evaluate whether the use of biliverdin (BV), a natural non-toxic antioxidant product of haeme catabolism, can suppress head and neck squamous cell carcinoma (HNSCC) cell proliferation and improve the tumour survival both in vitro and in vivo. Furthermore, we investigate whether this therapeutic outcome relies on BV’s potent antioxidant effect on reactive oxygen species (ROS)-mediated signalling.Methods:Two well-characterised HNSCC cell lines and a mouse model with… CONTINUE READING
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