Bilirubin produces apoptosis in cultured bovine brain endothelial cells.

  title={Bilirubin produces apoptosis in cultured bovine brain endothelial cells.},
  author={Eric D Akin and Ben R. Clower and Rita G Tibbs and Jiping Tang and Jie Zhang},
  journal={Brain research},
  volume={931 2},
Blood components such as oxyhemoglobin are believed to cause cerebral vasospasm by inducing contraction and cell death in cerebral arteries. We have observed previously that oxyhemoglobin produces apoptotic changes in cultured endothelial cells. This study was undertaken to explore if bilirubin, a bi-product of hemoglobin degradation, will produce similar cytotoxicity in endothelial cells. Cultured bovine brain microvascular endothelial cells were incubated in four concentrations of bilirubin… CONTINUE READING


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