Bilirubin oxidation products (BOXes) and their role in cerebral vasospasm after subarachnoid hemorrhage.

@article{Clark2006BilirubinOP,
  title={Bilirubin oxidation products (BOXes) and their role in cerebral vasospasm after subarachnoid hemorrhage.},
  author={J. F. Clark and Frank R. Sharp},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2006},
  volume={26 10},
  pages={
          1223-33
        }
}
Many factors have been postulated to cause delayed subarachnoid hemorrhage (SAH)-induced vasospasm, including hemoglobin, nitric oxide, endothelin, and free radicals. We propose that free radicals (because of the high levels that are produced in the blood clots surrounding blood vessels after SAH) act on bilirubin, biliverdin, and possibly heme to produce BOXes (Bilirubin OXidized Products). Bilirubin oxidation products act on vascular smooth muscle cells to produce chronic vasoconstriction and… CONTINUE READING
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