Bilirubin inhibits Plasmodium falciparum growth through the generation of reactive oxygen species.

@article{Kumar2008BilirubinIP,
  title={Bilirubin inhibits Plasmodium falciparum growth through the generation of reactive oxygen species.},
  author={Sanjay Kumar and Mithu Guha and Vinay Choubey and Pallab Maity and Kumkum Srivastava and Sunil K. Puri and Uday Bandyopadhyay},
  journal={Free radical biology & medicine},
  year={2008},
  volume={44 4},
  pages={
          602-13
        }
}
Free heme is very toxic because it generates highly reactive hydroxyl radicals ((.)OH) to cause oxidative damage. Detoxification of free heme by the heme oxygenase (HO) system is a very common phenomenon by which free heme is catabolized to form bilirubin as an end product. Interestingly, the malaria parasite, Plasmodium falciparum, lacks an HO system, but it forms hemozoin, mainly to detoxify free heme. Here, we report that bilirubin significantly induces oxidative stress in the parasite as… CONTINUE READING

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