Bilirubin-induced immunostimulant effects and toxicity vary with neural cell type and maturation state

@article{Falco2006BilirubininducedIE,
  title={Bilirubin-induced immunostimulant effects and toxicity vary with neural cell type and maturation state},
  author={Ana Sofia Falc{\~a}o and Adelaide Fernandes and Maria A. S. Brito and Rui Fernando Marques Silva and Dora Brites},
  journal={Acta Neuropathologica},
  year={2006},
  volume={112},
  pages={95-105}
}
Hyperbilirubinemia remains one of the most frequent clinical diagnoses in the neonatal period. The increased vulnerability of premature infants to unconjugated bilirubin (UCB)-induced brain damage may be due to a proneness of immature nerve cells to UCB-toxic stimulus. Thus, in this study, we evaluated UCB-induced cell death, glutamate release and cytokine production, in astrocytes and neurons cultured for different days, in order to relate the differentiation state with cell vulnerability to… CONTINUE READING

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