Bilirubin binding to myelin basic protein, histones and its inhibition in vitro of cerebellar protein synthesis.

@article{Gurba1974BilirubinBT,
  title={Bilirubin binding to myelin basic protein, histones and its inhibition in vitro of cerebellar protein synthesis.},
  author={P E Gurba and Robert Zand},
  journal={Biochemical and biophysical research communications},
  year={1974},
  volume={58 4},
  pages={1142-7}
}
The binding of unconjugated bilirubin to bovine CNS myelin basic protein and to lysine and arginine rich histones has been demonstrated by means of difference spectroscopy and circular dichroism spectroscopy. This is the first demonstration of a brain specific protein that can bind bilirubin and provides a mechanism for bilirubin retention in brain as well as a mechanism for interfering with the normal acidic lipid-basic protein binding interaction. The inhibition of protein synthesis in… CONTINUE READING

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