Bilirubin and brain: A pharmacological approach

  title={Bilirubin and brain: A pharmacological approach},
  author={C. Mancuso},
  • C. Mancuso
  • Published 2017
  • Chemistry, Medicine
  • Neuropharmacology
  • ABSTRACT For many decades, the world scientific literature has accounted for a number of works on the biological effects of bilirubin‐IXalpha (BR). The first studies focused on the neurotoxic effects of the excessive production of BR, in particular regarding both physiological neonatal jaundice and the more severe ones, typically as consequences of severe hemolysis or other underlying diseases. Only since 1987, has significant evidence, however, underlined the neuroprotective role of BR linked… CONTINUE READING
    29 Citations
    Metal Mediated Bilirubin Encephalopathy: Treatment with D-Penicillamine
    Mechanisms of redox interactions of bilirubin with copper and the effects of penicillamine.
    • 4
    • PDF
    Neuroprotective Effect of ω-3 Polyunsaturated Fatty Acids on Bilirubin Encephalopathy In Vitro and In Vivo
    • W. Hao, J. Song, G. Li
    • Medicine
    • Medical science monitor : international medical journal of experimental and clinical research
    • 2018
    • 1
    • PDF
    BRUP‐1, an intracellular bilirubin modulator, exerts neuroprotective activity in a cellular Parkinson’s disease model
    • 2
    Celecoxib Exerts Neuroprotective Effects in β-Amyloid-Treated SH-SY5Y Cells Through the Regulation of Heme Oxygenase-1: Novel Insights for an Old Drug


    The Evolving Landscape of Neurotoxicity by Unconjugated Bilirubin: Role of Glial Cells and Inflammation
    • 91
    • PDF
    New insights in bilirubin metabolism and their clinical implications.
    • 97
    A Novel Perspective on the Biology of Bilirubin in Health and Disease.
    • 59
    • PDF
    Oxidative and nitrosative modifications of biliverdin reductase-A in the brain of subjects with Alzheimer's disease and amnestic mild cognitive impairment.
    • 73
    • PDF