Bilirubin and biliverdin protect rodents against diabetic nephropathy by downregulating NAD(P)H oxidase.

@article{Fujii2010BilirubinAB,
  title={Bilirubin and biliverdin protect rodents against diabetic nephropathy by downregulating NAD(P)H oxidase.},
  author={Masakazu Fujii and Toyoshi Inoguchi and Shuji Sasaki and Yasutaka Maeda and Jing Zheng and Kunihisa Kobayashi and Ryoichi Takayanagi},
  journal={Kidney international},
  year={2010},
  volume={78 9},
  pages={905-19}
}
We recently found a markedly lower prevalence of vascular complications, including kidney disease, in diabetic patients with Gilbert syndrome, a congenital form of hyperbilirubinemia, suggesting a beneficial effect of bilirubin (BIL) on diabetic nephropathy. To directly examine this, we determined whether hereditary hyperbilirubinemic Gunn j/j rats and biliverdin (BVD)-treated diabetic db/db mice were resistant to the development of renal disease. Both rodent models had less albuminuria and… CONTINUE READING
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