Bilirubin Exerts Additional Toxic Effects in Hypoxic Cultured Neurons from the Developing Rat Brain by the Recruitment of Glutamate Neurotoxicity

@article{Grojean2001BilirubinEA,
  title={Bilirubin Exerts Additional Toxic Effects in Hypoxic Cultured Neurons from the Developing Rat Brain by the Recruitment of Glutamate Neurotoxicity},
  author={St{\'e}phanie Grojean and Val{\'e}rie Li{\`e}vre and Violette Koziel and Paul Vert and Jean-Luc Daval},
  journal={Pediatric Research},
  year={2001},
  volume={49},
  pages={507-513}
}
Both hypoxia and bilirubin are common risk factors in newborns, which may act synergistically to produce anatomical and functional disturbances of the CNS. Using primary cultures of neurons from the fetal rat brain, it was recently reported that neuronal apoptosis accounts for the deleterious consequences of these two insults. To investigate the influence of hypoxia, bilirubin, or their combination on the outcome of neuronal cells of the immature brain, and delineate cellular mechanisms… CONTINUE READING
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