Biliary secretion of S-nitrosoglutathione is involved in the hypercholeresis induced by ursodeoxycholic acid in the normal rat.

@article{RodrguezOrtigosa2010BiliarySO,
  title={Biliary secretion of S-nitrosoglutathione is involved in the hypercholeresis induced by ursodeoxycholic acid in the normal rat.},
  author={Carlos M. Rodr{\'i}guez-Ortigosa and Jes{\'u}s Mar{\'i}a Banales and Israel Olivas and I. R. Uriarte and Jose J. G. Marin and Fernando Jos{\'e} Corrales and Juan Francisco Villa Medina and Jes{\'u}s Prieto},
  journal={Hepatology},
  year={2010},
  volume={52 2},
  pages={
          667-77
        }
}
UNLABELLED Ursodeoxycholic acid (UDCA) induces bicarbonate-rich hypercholeresis by incompletely defined mechanisms that involve the stimulation of adenosine triphosphate (ATP) release from cholangiocytes. As nitric oxide (NO) at a low concentration can stimulate a variety of secretory processes, we investigated whether this mediator could be implicated in the choleretic response to UDCA. Our in vivo experiments with the in situ perfused rat liver model in anesthetized rats, showed that UDCA… CONTINUE READING
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Drug Insight: mechanisms and sites of action of ursodeoxycholic acid in cholestasis

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